In order to solve the problem of refusal or misoperation in the staged current protection of the existing centralized photovoltaic power station, a simulation model for the boosted grid connection of the centralized photovoltaic power station is established, which combines the control target of the inverter and the output characteristics of the photovoltaic itself. The analytical expression of the steady-state short-circuit current provided by the photovoltaic side is derived. On the basis of expressions, the adaptability of traditional fault analysis and protection schemes is analyzed one by one when fault occurs on the overhead line, the collection cable, and the current collection line respectively. In view of the shortcomings of the original backup protection when the overhead line fails, the distance protection at the downstream collecting station side is proposed to replace the original staged current protection. For the existing protection scheme, it is difficult to distinguish the collecting line fault from the collecting cable fault. Then, inverse time protection scheme is proposed. PSCAD simulation results show that the proposed protection scheme can reliably operate on common fault types.