Based on the structural attributes of DC microgrid and diverse micro-sources’ features, the constant DC bus voltage is considered as the control target. For the situation that each unit belongs to different users, the multi-agent system is used to construct the information network, and a DC microgrid regional stability control method based on distributed power self-coordination, self-management and self-organizing network is proposed. The independent sub-region in the DC microgrid system is chosen as the research object, and the system stability control method under different supply and demand is designed to realize the redistribution and optimization of the power supply based on the interactive information. The simulation results demonstrate that the proposed method can be used to maintain the stability of the system, and it can fully reflect the running characteristics of different distributed power supply.